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No process or function of our body can take place without O2
Oxygen is essential for mitochondrial respiration and oxidative phosphorylation. In other words, it provides nourishment for maintaining life and growth.
When we breathe air with depleted amounts of oxygen, our body’s processes compensate for the lack of oxygen by using other resources and functions. Compensation comes at a high price as our bodies are forced to perform but with less efficiency, causing the body to wear (age).
Here's An Example
Think about an engine (our bodies) overheating due to the lack of coolant (Oxygen). The engine makes compensation by utilizing other resources (fan, oil, and airflow) to stop overheating, but these systems were not designed to correct the problem. Although they assist in cooling, they were designed as support functions. If the car continues to rely on the secondary systems, it will experience severe degradation and failure (engine wear, seizure, or blown engine).